Effects of cyclophosphamide on rat placental development

We examined the morphological effects of cyclophosphamide (CPA) on placental development in pregnant rats. CPA was administered as a single dose to rats intraperitoneally at 0 mg/kg (the control group), 25 gestation day (GD) 12 GD 12-treated and 14 14-treated group). The fetal weight decreased CPA-treated groups, complete resorption from 17 onwards group, external malformations group. Histopathologically, induced apoptosis and/or cell proliferation inhibition each part placenta. In labyrinth zone, syncytiotrophoblasts were selectively reduced, resulting small basal number spongiotrophoblasts hypoplasia glycogen islands. addition, interstitial trophoblasts invaded metrial gland zone 15. severity these lesions higher group than gland, although uterine natural killer cells not affected.